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KMID : 0861020090240020001
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Korea Journal of Herbology
2009 Volume.24 No. 2 p.1 ~ p.5
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Effect of Hwangryunhaedok-tang Extracts on DNCB-induced Allergic Contact Dermatitis
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Kim Bo-Ae
Yang Jae-Chan
Park Chan-Ik
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Abstract
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Objectives : HRHDT has been known as a useful prescription with antibiotic, anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-inflammatory effect of HRHDT, we treated HRHDT-skin in Balb/c mice model induced contact hypersensitivity.
Methods : Contact hypersensitivity, a local inflammatory respinse of skin, was induced by spreading the back skin of Balb/c mice with 1% DNCB. HRHDT-skin was prepared by dissolving 3% 1,3-butylene glycol extract of HRHDT in solution and treated 2 weeks on the back skin.
Results: HRHDT-skin significantly reduced TEWL and erythema by 0.4-1% of DNCB treatment compared with control group. HRHDT-skin reduced IgE on serum obtained from blood of DNCB-treated Balb/c mice. Histopathological examination showed that thickening of the epidermis, hyperkeratosis and the infiltration of inflammatory cells were found in Balb/c mice under conventional circumstances.
Conclusions : These results showed that HRHDT-skin could be used as a pharmaceutical material with antiinflammatory effects by reducing IgE in contact hypersensitivity dermatitis Balb/c mice by DNCB.
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KEYWORD
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Hwangryunhaedok-tang (HRHDT), Contact hypersensitivity, Balb/c mice, DNCB, IgE, H&E stain
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